# Illumina — developer ecosystem report

> Illumina Open Source Software

- GitHub org: `Illumina`
- Category: dev_tool
- Overall score: 41.0 / 100
- Overall rank: #440
- Last refreshed: 2026-08-21

## Pillar scores

| Pillar | Score / 100 | Rank | Weight in overall |
| --- | --- | --- | --- |
| Code & Polish | 46.0 | #556 | ~22% |
| Education | 67.0 | #431 | ~18% |
| AI readiness | 18.0 | #619 | part of Reach |
| Builder experience | 0.0 | #1 | ~12% |
| Community | 52.0 | #127 | ~16% |
| Reach | 64.0 | #123 | ~18% |
| Momentum | 0.0 | #917 | ~14% |

## Links

- GitHub: https://github.com/Illumina
- Website: http://www.illumina.com
- Docs: https://developer.illumina.com

## Public GitHub totals

| Metric | Value |
| --- | --- |
| Repos analyzed | 12 |
| Stars | 4,287 |
| Forks | 1,175 |
| Open issues | 962 |
| Contributors | — |

## Top repositories

| Repo | Stars | Language | Description |
| --- | --- | --- | --- |
| [SpliceAI](https://github.com/Illumina/SpliceAI) | 506 | Python | A deep learning-based tool to identify splice variants |
| [hap.py](https://github.com/Illumina/hap.py) | 471 | C++ | Haplotype VCF comparison tools |
| [manta](https://github.com/Illumina/manta) | 468 | C++ | Structural variant and indel caller for mapped sequencing data |
| [strelka](https://github.com/Illumina/strelka) | 394 | C++ | Strelka2 germline and somatic small variant caller |
| [ExpansionHunter](https://github.com/Illumina/ExpansionHunter) | 217 | C++ | A tool for estimating repeat sizes |
| [Nirvana](https://github.com/Illumina/Nirvana) | 197 | C# | The nimble & robust variant annotator |
| [DRAGMAP](https://github.com/Illumina/DRAGMAP) | 189 | C++ | DRAGEN open-source mapper |
| [paragraph](https://github.com/Illumina/paragraph) | 170 | C++ | Graph realignment tools for structural variants |
| [pyflow](https://github.com/Illumina/pyflow) | 148 | Python | A lightweight parallel task engine |
| [canvas](https://github.com/Illumina/canvas) | 129 | C# | Canvas - Copy number variant (CNV) calling from DNA sequencing data |
| [PrimateAI](https://github.com/Illumina/PrimateAI) | 118 | Python | deep residual neural network for classifying the pathogenicity of missense mutations. |
| [PromoterAI](https://github.com/Illumina/PromoterAI) | 99 | Python | — |

## Methodology

Scores are computed from public signals only (GitHub, package registries, docs sites, community platforms). Pillar definitions: https://www.smoower.com/docs.md

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